克罗米衍生物对男性低促性腺素性功能减退症有效

明尼阿波利斯（汤姆森社有益版）1月四日华盛顿邮报：据刊登在12月再版的《怀孕与生子》时尚杂志的一项研究报告指出克罗米苯对部分较高促性腺素在广泛性减退的男性人症状利于。来自考文垂新罕布什尔大学的该研究报告的第一作者Scott J. Whitten指导教授在不能接受汤姆森通讯社采访谈及：“病变或获得性HH症状在不能接受侵害性巨大和极为高昂的病人（例如注射促性腺激素在类）前顺利完成4个月的克罗米苯试验性病人是利于的。”Whitten指导教授和同事分析了克罗米苯对10名HH男性人症状（HH是导致男性人生子的少见因素在）是否有效率。研究报告称克罗米苯病人1年后，4名卡尔曼(氏)病症症状中所只有一名症状的胎盘酸度增大而全垂体功能减退症症状的胎盘缺乏症状均不能赢取改善。相反，该研究报告指出3名男性患病的病变HH男性人症状经过3个月克罗米苯的病人胎盘酸度有了明显增大。迄今为止该组症状就有两名直至了身体健康。Whitten指导教授时说：“除非对克罗米苯病人不能反应会，我们不会因为副作用停止对症状使用该药物。”最后作者总结时说：“因为前提有限，对HH症状促性腺激素在苯和克罗米苯的随机分析难以顺利完成，然而利用多系列的严格选择基准对症状顺利完成分级可能帮助再进一步验证克罗米苯直至男性人较高身体健康的有效率性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编辑：蓝色宿命

编辑： 张靖